Eguren, M., Porlan, E., Manchado, E., Garcia-Higuera, I., Canamero, M., Farinas, I. and Malumbres, M. (2013). «The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.» Nat Commun 4: 2880.

The E3-ubiquitin ligase APC/C-Cdh1 is essential for endoreduplication but its [...]

Por |2026-06-02T17:44:38+01:0013 de noviembre de 2020||Comentarios desactivados en Eguren, M., Porlan, E., Manchado, E., Garcia-Higuera, I., Canamero, M., Farinas, I. and Malumbres, M. (2013). «The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.» Nat Commun 4: 2880.
Más información

Marques-Torrejon, M. A., Porlan, E., Banito, A., Gomez-Ibarlucea, E., Lopez-Contreras, A. J., Fernandez-Capetillo, O., Vidal, A., Gil, J., Torres, J. and Farinas, I. (2013). «Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.» Cell Stem Cell 12(1): 88-100.

In the adult brain, continual neurogenesis of olfactory neurons is [...]

Por |2026-06-02T17:44:38+01:0013 de noviembre de 2020||Comentarios desactivados en Marques-Torrejon, M. A., Porlan, E., Banito, A., Gomez-Ibarlucea, E., Lopez-Contreras, A. J., Fernandez-Capetillo, O., Vidal, A., Gil, J., Torres, J. and Farinas, I. (2013). «Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.» Cell Stem Cell 12(1): 88-100.
Más información

Porlan, E., Morante-Redolat, J. M., Marques-Torrejon, M. A., Andreu-Agullo, C., Carneiro, C., Gomez-Ibarlucea, E., Soto, A., Vidal, A., Ferron, S. R. and Farinas, I. (2013). «Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance.» Nat Neurosci 16(11): 1567-1575.

Relative quiescence and self renewal are defining features of adult [...]

Por |2026-06-02T17:44:38+01:0013 de noviembre de 2020||Comentarios desactivados en Porlan, E., Morante-Redolat, J. M., Marques-Torrejon, M. A., Andreu-Agullo, C., Carneiro, C., Gomez-Ibarlucea, E., Soto, A., Vidal, A., Ferron, S. R. and Farinas, I. (2013). «Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenance.» Nat Neurosci 16(11): 1567-1575.
Más información

Ferron, S. R., Charalambous, M., Radford, E., McEwen, K., Wildner, H., Hind, E., Morante-Redolat, J. M., Laborda, J., Guillemot, F., Bauer, S. R., Farinas, I. and Ferguson-Smith, A. C. (2011). «Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.» Nature 475(7356): 381-385.

The gene for the atypical NOTCH ligand delta-like homologue 1 [...]

Por |2026-06-02T17:44:38+01:0011 de noviembre de 2020||Comentarios desactivados en Ferron, S. R., Charalambous, M., Radford, E., McEwen, K., Wildner, H., Hind, E., Morante-Redolat, J. M., Laborda, J., Guillemot, F., Bauer, S. R., Farinas, I. and Ferguson-Smith, A. C. (2011). «Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.» Nature 475(7356): 381-385.
Más información

Ferron, S. R., Pozo, N., Laguna, A., Aranda, S., Porlan, E., Moreno, M., Fillat, C., de la Luna, S., Sanchez, P., Arbones, M. L. and Farinas, I. (2010). «Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.» Cell Stem Cell 7(3): 367-379.

Stem cell division can result in two sibling cells exhibiting [...]

Por |2026-06-02T17:44:38+01:0010 de noviembre de 2020||Comentarios desactivados en Ferron, S. R., Pozo, N., Laguna, A., Aranda, S., Porlan, E., Moreno, M., Fillat, C., de la Luna, S., Sanchez, P., Arbones, M. L. and Farinas, I. (2010). «Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.» Cell Stem Cell 7(3): 367-379.
Más información

Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortiguela, R., Marques-Torrejon, M. A., Nakashima, K., Colak, D., Gotz, M., Farinas, I. and Gage, F. H. (2010). «Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.» Cell Stem Cell 7(1): 78-89.

Neural stem cells (NSCs) in the adult hippocampus divide infrequently, [...]

Por |2026-06-02T17:44:38+01:0010 de noviembre de 2020||2 Comentarios
Más información

Ferron, S. R., Marques-Torrejon, M. A., Mira, H., Flores, I., Taylor, K., Blasco, M. A. and Farinas, I. (2009). «Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.» J Neurosci 29(46): 14394-14407.

Proliferation in the subependymal zone (SEZ) and neurogenesis in the [...]

Por |2026-06-02T17:44:38+01:009 de noviembre de 2020||Comentarios desactivados en Ferron, S. R., Marques-Torrejon, M. A., Mira, H., Flores, I., Taylor, K., Blasco, M. A. and Farinas, I. (2009). «Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis.» J Neurosci 29(46): 14394-14407.
Más información

Folgueras, A. R., Valdes-Sanchez, T., Llano, E., Menendez, L., Baamonde, A., Denlinger, B. L., Belmonte, C., Juarez, L., Lastra, A., Garcia-Suarez, O., Astudillo, A., Kirstein, M., Pendas, A. M., Farinas, I. and Lopez-Otin, C. (2009). «Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.» Proc Natl Acad Sci U S A 106(38): 16451-16456.

Peripheral interactions between nociceptive fibers and mast cells contribute to [...]

Por |2026-06-02T17:44:38+01:009 de noviembre de 2020||Comentarios desactivados en Folgueras, A. R., Valdes-Sanchez, T., Llano, E., Menendez, L., Baamonde, A., Denlinger, B. L., Belmonte, C., Juarez, L., Lastra, A., Garcia-Suarez, O., Astudillo, A., Kirstein, M., Pendas, A. M., Farinas, I. and Lopez-Otin, C. (2009). «Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.» Proc Natl Acad Sci U S A 106(38): 16451-16456.
Más información

Wu, H. H., Bellmunt, E., Scheib, J. L., Venegas, V., Burkert, C., Reichardt, L. F., Zhou, Z., Farinas, I. and Carter, B. D. (2009). «Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.» Nat Neurosci 12(12): 1534-1541.

During the development of peripheral ganglia, 50% of the neurons [...]

Por |2026-06-02T17:44:38+01:009 de noviembre de 2020||Comentarios desactivados en Wu, H. H., Bellmunt, E., Scheib, J. L., Venegas, V., Burkert, C., Reichardt, L. F., Zhou, Z., Farinas, I. and Carter, B. D. (2009). «Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.» Nat Neurosci 12(12): 1534-1541.
Más información
Ir a Arriba